ObjectiveTo investigate the diagnostic value of sound speed correction(SSC) for the severity of liver fibrosis in the patients with chronic hepatitis B. MethodsA total of 137 patients clinically diagnosed as chronic hepatitis B were enrolled as study group, and 21 healthy volunteers as control group during the same period. The patients of the study groups were divided into liver fibrosis S0 group, S1 group, S2 group, S3 group and S4 group according to pathological types of hepatic tissues. The zone speed index(ZSI) and zone sound speed(ZSS) of each group were measure by SSC technique. The ZSI and ZSS were compared among all groups for evaluate the diagnostic value of ZSI and ZSS for the severity of liver fibrosis in the patients with chronic hepatitis B. ResultsThe ZSI of the chronic hepatitis B patients with stage S0, S1, S2, S3 and S4 of liver fibrosis were（18.78±4.28）m/s，（22.24±4.20）m/s，（27.66±3.35）m/s，（30.47±3.68）m/s，（35.36±4.0）m/s，respectively. The ZSS of the patients with stage S0, S1, S2, S3 and S4 were（1 558.91±4.38）m/s,（1 562.42±4.22）m/s,（1 567.81±3.33）m/s,（1 570.63±3.69）m/s and （1 575.57±4.12）m/s. respectively. The area under the ROC curve of ZSI was 0.854 for diagnosing stage S1-S4 liver fibrosis in patients with chronic hepatitis B(95% CI:0.796, 0.912). When the cut-off value of ZSI was 21.88 m/s, the diagnostic sensitivity and specificity for liver fibrosis were 80.60% and 74.70%, respectively. The area under the ROC curve of ZSS was 0.854 for diagnosing liver fibrosis in patients with chronic hepatitis B (95% CI: 0.795, 0.911). When the cut-off value of ZSS was 1561.5 m/s, the diagnostic sensitivity and specificity for liver fibrosis were 80.60% and 75.80%, respectively. ConclusionZSI and ZSS can achieve a certain diagnostic value and similar diagnostic efficacy for liver fibrosis in the patients with chronic hepatitis B. SSC can be used as a technique for evaluation of liver fibrosis.

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