ObjectiveTo investigate expressions and significance of caudal type homeo box transcription factor 2 (CDX2), nuclear factor kappa B (NF-κB) and mucin 2 (MUC2) in Barrett esophagus(BE) . MethodsThe detection rate of BE complicated with intestinal metaplasia (IM) was compared between biopsy with conventional white light endoscopy and biopsy with narrow band imaging(NBI) mode on the basis of the randomized controlled method. The expressions of CDX2, NF-κB and MUC2 were detected in BE (after screening with NBI) , normal esophageal mucosa and esophageal adenocarcinoma(EAC) tissues by immunohistochemical method. ResultsThe detection rate of BE complicated with IM in the NBI group was higher than that in the endoscopy group［65.8%(25/38) vs 34.2%(13/38), P＜0.05］. The positive rates of CDX2 in the normal esophageal mucosa, BE and EAC tissues were 0, 73.3%（22/30）and 33.3%（10/30） respectively. The positive rates of NF-κB in the normal esophageal mucosa, BE and EAC tissues were 6.7%（2/30）, 66.7%（20/30）and 40.0%（12/30）respectively. The positive rates of MUC2 in the normal esophageal mucosa, BE and EAC tissues were 0, 60.0%（18/30）and 26.7%（8/30） respectively. There were significant differences in the positive rates of CDX2, NF-κB and MUC2 among the three tissues（P＜0.05）. The positive rates of CDX2 positively correlated to the positive rate of NF-κB(r=0.869)or MUC2(r=0.820). ConclusionNBI can effectively improve the pathological detection rate of BE complicated with IM. Activation of CDX2, NF-κB and MUC2 may induce IM and malignant transformation in BE.

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