ObjectiveTo assess the clinical efficacy of endoscopic selective varices devascularization and traditional sequential therapy for esophagogastric varicose. MethodsOf 64 esophagogastric varicose patients receiving endoscopic therapy, 39 patients(control group) received traditional sequential therapy (esophageal variceal sclerotherapy and injection of tissue adhesive by sandwich technique in gastric varices) and 25 patients(observation group) received esophagogastric selective varices devascularization (lauromacrogol,tissue adhesive, air and normal saline). The success rate of hemostasis, rate of varicose disappearance, incident rate of complications, rate of recurrent bleeding and frequency of treatment were compared between the two groups. ResultsDuring the 3-month follow-up, the frequency of treatment ［(2.76±0.83) times vs.(1.52±0.58) times］was more, the consumptionof lauromacrogol ［(43.45±23.16)mL vs.(46.36±26.35)mL］ and tissue adhesive［2.0（1.5～4.0）mL vs 3.0（1.75～4.5）mL］ were less in the control group compared to the observation group（P＜0.01）.The hemostatie rates were 100% in both groups. The rates of recurrent bleeding in the control group and the observation group were 17.9%（7/39） and 12.0%（3/25）respectively, but there was no significant difference between the two groups（P＞0.05）. The rate of postoperative venous disappearance in the control group was lower than that in the observation group［15.4%（6/39） vs. 40.0%（10/25），P＜0.05］. There was no significant difference in the incident rate of complications between the two groups（P＞0.05）. ConclusionEndoscopic selective varices devascularization obtains a significant efficacy, low recurrence rate, less treatment and high safety.

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