ObjectiveTo compare the efficacy between retroperitoneal and transperitoneal approaches for laparoscopic radical nephrectomy. MethodsClinical data of 28 patients receiving selective laparoscopic radical nephrectomy were retrospectively analyzed. Fourteen patients underwent laparoscopic radical nephrectomy via retroperitoneal approach(observation group) and the other 14 patients via transperitoneal approach(control group). Postoperative follow-up of 24 months was performed in both groups. ResultsThe operative duration, intraoperative blood loss and duration for postoperative exhausting in the observation group were shorter or less than those in the control group(all P＜0.05) .There were no significant differences in the the incident rate of systemic inflammatory response syndrome，postoperative hospital stay and incident rate of postoperative complications between the two groups(all P＞0.05). During the 24-month follow-up, distal metastasis occurred in one case of the control group, and no recrudesce or metastasis was found in the other patients. ConclusionLaparoscopic nephrectomy via retroperitoneal approach can shorten the operative duration, decrease the intraoperative blood loss, and can achieve faster gastrointestinal recovery compared to transperitoneal approach. However, there was no obvious difference in the incidence of complications and outcome between the two approaches.

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