ObjectiveTo explore the distribution characteristics and its significance of EV71 receptors SCARB2 and PSGL-1 in multiple human tissues and organs. MethodsThe expressions of EV71 receptor SCARB2 and PSGL-1 in the tissues of central nervous system, respiratory tract, intestinal tract, liver, spleen and heart were detected by immunohistochemistry. ResultsThe positive expression of SCARB2 was observed in the cerebrum, cerebellum and brain stem of the central nervous system, throat, trachea, bronchus, bronchioles, alveolar cells and macrophages of respiratory tract and intestinal tissues, the weakly positive or negative expression in the liver, and the negative expression in the spleen and heart. The expression levels of SCARB2 in the central nervous system, respiratory tract or intestinal tract was significantly higher in that in the liver spleen or heart（P＜0.05）. The positive expression of PSGL-1 was observed in the cerebrum, cerebellum and brain stem of the central nervous system and the throat of respiratory tract, the weakly positive expression in the trachea and bronchus of the respiratory tract and intestinal tract, the negative expression in the alveolar cell, and the negative or extremely weakly positive expression in the liver, spleen and heart. The expression level of PSGL-1 in the central nervous system was significantly higher than that in the respiratory tract, intestine, liver, spleen or heart（all P＜0.05）. The expression level of PSGL-1 in the respiratory tract or intestine was significantly higher than that in the liver, spleen or heart（all P＜0.05）. ConclusionThe EV71 receptor SCARB2 and/or PSGL-1 expressed in the central nervous system, respiratory tract and intestinal tract, which suggests that those organs and tissues above are the main sites EV71 infected.

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