【Abstract】 ObjectiveTo explore the clinical efficacy of radiofrequency ablation using low temperature plasma knife for the treatment of early glottic carcinoma. MethodsTwentyeight patients with early glottic carcinoma were enrolled, and were randomly divided into radiofrequency group and control group, with 14 cases in each group. The radiofrequency group and control group underwent radiofrequency ablation using low temperature plasma knife and partial excision for glottic carcinoma,respectively. The preoperative and 1month postoperative grades of glottic morphology, and incidence of complication within 1 month after operation were compared between the two groups. The survival rates and tumor recurrence at 6month and 2year after operation were analyzed. ResultsAt 1 month after operation, the excellent rates of glottic morphology grading in both groups were improved compared the preoperative rates, and the rate of the radiofrequency group was significantly higher than the rate of the control group（P＜0.05）. The incident rate of postoperative complications in the radiofrequency group was significantly lower than the rate of the control group（P＜0.05）. At 6 months after operation, there were no significant differences in the tumor recurrence and survival rate between the two groups （all P＞0.05）. At 2 years after operation, the tumor recurrence of the radiofrequency group was significantly lower than the rate of the control group（P＜0.05）, but no significant difference in the survival rate was found between the two groups （P＞0.05）. ConclusionRadiofrequency ablation using low temperature plasma knife can achieve good efficacy and outcome for the treatment of early glottic carcinoma.

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