【Abstract】 ObjectiveTo investigate the expressions and biological significance of CD80 and CD86 in nasopharyngeal carcinoma. MethodsThe expressions of CD80 and CD86 were detected by immunohistochemical stain in 26 cases of nasopharyngeal carcinoma tissues(including 13 poorly differentiated cases and 13 undifferentiated cases) and 11 cases of normal nasopharyngeal tissues. ResultsThe positive rates of CD80 and CD86 in the nasopharyngeal carcinoma tissues and normal nasopharyngeal tissues were 61.54%(16/26) and 100.00%(11/11) respectively. The average grey values (AGV) of CD80 in the positive nasopharyngeal carcinoma tissues and normal nasopharyngeal tissues were （41.53±5.81）and （73.93 ±6.45）respectively. According to the analysis of PISA2000 images, the average grey values (AGV) of CD80 in the positive nasopharyngeal carcinoma tissues and normal nasopharyngeal tissues were（41.53±5.81）and （73.93±6.45）respectively. The AGVs of CD86 in the positive nasopharyngeal carcinoma tissues and normal nasopharyngeal tissues were（42.44±4.12）and（73.60±6.42）respectively. And significant differences in the AGVs were found between the two groups(P＜0.05).The positive rates of CD80 and CD86 in the poorly differentiated tissues and undifferentiated tissues were 84.61%（11/13）and 38.46% (5/13）respectively（P＜0.05）. ConclusionThe expressions of CD80 and CD86 in the cancer tissues are lower than those in the normal tissue. CD80 and CD86 mainly expressed in cytoplasm and nucleus, and their expressions decreased with the decrease of differentiation.

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