目的 研究腹腔镜胆囊切除术对老年胆囊结石患者术后Il-6、C反应蛋白及疲劳综合征的影响。方法 将54例老年胆囊结石患者采用单双号法分为对照组和观察组各27例,其中对照组行开腹胆囊切除术,观察组行腹腔镜胆囊切除术,观察两组患者手术前后Il-6、C反应蛋白水平,并记录疲劳指数变化情况。结果 两组患者术前第1天IL-6、C反应蛋白值比较,差异无统计学意义(P>0.05),术后第2天观察组患者的IL-6、C反应蛋白分别为(34.51±5.29)ρ/ng·L-1、(12.67±2.55)ρ/ng·L-1,均较对照组低,差异有统计学意义(P<0.05)。两组患者术后疲劳综合指数均呈明显下降趋势,观察组下降幅度较对照组明显,差异具有统计学意义(P<0.05)。结论 采用腹腔镜胆囊切除术治疗老年胆囊结石,能够降低机体应激反应,提高手术治疗质量,值得推广应用。
Objective To investigate the influence of laparoscopic cholecystectomy treating for elderly patients with cholelithiasis on the post operative serum level of IL6,CRP and chronic fatigue syndrome. Methods 54 elderly cases of cholelithiasis were divided into two groups based on oddeven number. The observation group was given laparoscopic cholecystectomy,and the control group was performed open cholecystectomy. The perioperative serum levels of IL6 and CRP were observed,and the fatigue index was also recorded. Results The preoperative serum level of IL6 and CRP had no difference between groups. The 1day postoperative serum level of IL6 and CRP in the observation group were (34. 51 ±5. 29)ρ/ ngoL1, (12. 67 ±2. 55 )ρ/ ngoL1, respectively, both significantly lower than those of the control group. The postoperative fatigue index had a decline in both groups,and the drop in the observation group was lager than that of the control group. Conclusion Laparoscopic cholecystectomy treating for elderly patients with cholelithiasis has the advantages of less stress response,higher quality of life compared with open cholecystectomy,worthy of clinical promotion.