【Abstract】 ObjectiveTo explore the effect of preoperative atorvastatin therapy on coronary flow and inflammatory mediators in patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). MethodsFortyone patients with acute STEMI treated with atorvastatin before and after PCI were selected as observation group, and 41 patients with acute STEMI treated with atorvastatin only after PCI as control group.The coronary blood flow and inflammatory mediators level after PCI were compared between the two groups. ResultsAfter PCI, the blood flow classification of thrombolysis in myocardial infarction (TIMI) in both groups were significantly improved compared with the preoperative classification(P＜0.05). But there was no significant difference in the TIMI blood flow classification between the two groups (P＞0.05).After PCI, the noreflow rate of infarcted artery in the observation group was significantly lower than that of the control group ［7.32% (3/41) vs. 21.95%(9/41), P＜0.05］. The rate of complete STsegment resolution in the observation group was higher than that in the control group ［95.12% (39/41) vs. 80.49%(33/41), P＜0.05］. After PCI, the inflammatory mediators levels of the patients in both groups significantly decreased compared with preoperative levels (P＜0.05), and the levels of the indicators above in the observation group was significantly lower than those in the control group (P＜0.05). ConclusionPreoperative atorvastatin therapy can reduce the release of serum inflammatory mediators in patients with acute STEMI, improve the blood perfusion, and reduce the risk of postoperative noreflow.

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