【Abstract】 ObjectiveTo observe the efficacy of intratympanic administration with dexamethasone through eustachian tube combined with desloratadine in treatment of secretory otitis media and its effect on function of eustachian tube. MethodSeventysix patients with secretory otitis media were randomly divided into observation group and control group. The control group received intratympanic administration with dexamethasone through eustachian. The observation group received intratympanic administration with dexamethasone through eustachian and oral administration of desloratadine. The therapeutic efficacy and the function of eustachian tube were compared between the two groups. ResultThe efficacy of the observation group was superior to that of the control group at one week and one month after treatment（P＜0.05）. Threemonth followup was performed after treatment for detection of the function of eustachian tube. Before treatment, there was no significant difference in the rate of eustachian tube dysfunction between the two groups(P＜0.05). The rates of eustachian tube dysfunction in both groups after treatment were significantly lower than those before treatment(P＜0.05). After treatment, the rates of eustachian tube dysfunction in the observation group was lower than that in the control group (P＜0.05). The recovery rate of the eustachian tube functional in the observation group was significantly higher than that in the control group (P＜0.05) . ConclusionFor the treatment of secretory otitis media, intratympanic administration with dexamethasone through eustachian tube combined with desloratadine can decrease exudation, improve the function of eustachian tube and promote the recovery of hearing.

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