目的 观察电视胸腔镜下肺叶切除术治疗非小细胞肺癌的临床疗效。方法 将经明确诊断为非小细胞肺癌且符合手术治疗的82例患者,随机分为观察组和对照组各41例,对照组采用传统肺叶切除术,观察组采用电视胸腔镜肺叶切除术,观察两组术中、术后情况、2年复发率和转移率及生存率。结果 观察组术中失血量、术后总引流量、引流管留置时间、术后住院时间、镇痛药使用次数均短于或少于对照组,上述指标比较,差异有统计学意义(P<0.05);两组在手术时间、淋巴结清扫个数方面比较,差异无统计学意义。观察组发生并发症4例(9.76%),对照组发生13例(31.70%),两组术后并发症发生率比较,差异有统计学意义(χ2=4.75,P<0.05)。观察组41例中失访4例,随访率为90.24%,随访期间发生远处转移2例(4.88%),发生纵膈淋巴结转移5例(12.19%),2年无瘤生存期为87.80%(35/41),随访期间有3例死亡,2年生存率为87.80%(36/41)。对照组41例中失访3例,随访率为92.68%,随访期间发生远处转移6例(14.63%),发生纵膈淋巴结转移5例(12.19%),2年无瘤生存期为73.17%(30/41)。随访期间8例死于晚期肿瘤,2年生存率为80.78%(33/41)。两组2年无瘤生存期经卡方检验,不具有显著性差异。两组2年生存率比较,差异有统计学意义(χ2=4.22,P<0.05)。结论 VATS肺叶切除术可作为Ⅰ、Ⅱ期非小细胞肺癌的手术术式,可降低术后并发症发生率,具有肿瘤学治疗安全性。
Objective To observe the clinical curative effect of nonsmall cell lung cancer treated by videoassisted thoracoscopic lobectomy. Methods 82 cases diagnosed with nonsmall cell lung cancer were randomly divided into the control group and the control group,41 cases each group. Traditional lobectomy was performed in the observation group,while videoassisted thoracoscopic lobectomy was performed tin the observation group. Intraoperative and postoperative situations,2year rates of metastasis,recurrence and survival were compared. Results The intraoperative blood loss,the total flow and drainage tube indwelling, length of hospital stay,postoperative analgesia drug use frequency of the observation group were shorter or less than those of the control group (P <0. 05). There was no difference in terms of the number of dissected lymph nodes and the operation time. There were complications in 4 cases in the observation group(9. 76% ),and 13 cases in the control group(31. 70% )(P < 0. 05). In the observation group,4 cases were lost followup, 2 cases had distant metastasis (4. 88% ),5 cases had mediastinal lymph node metastases (12. 19% ),and 2year diseasefree survival rate was 87. 80% (35 /41),3 cases died during the followup period,and 2year survival rate was 87. 80% (36 /41). Of the control group,3 were lost to followup,with the followup rate of 92. 68% ,6 cases had distant metastasis (14. 63% ),5 cases had mediastinal lymph node metastases(12. 19% ),2year diseasefree survival rate was 73. 17% (30 /41),8 patients died of advanced cancer during the followup period,2year survival rate was 80. 78% (33 /41). The 2year diseasefree survival rate showed no significant difference,and the 2year survival rate showed significant difference (χ2 = 4. 22, P <0. 05). Conclusion VATS lobectomy treating for Ⅰ,Ⅱ stage nonsmall cell lung cancer results in fewer postoperative complications than thoracotomy,showing security of oncology therapy.