ObjectiveTo investigate the effect of different doses of fentanyl combined with propofol in the perioperative period of laparoscopic surgery in young and middle-aged women. MethodsA total of 57 cases of gynecologic patients scheduled for laparoscopic surgery were randomly divided into three groups: group A, group B and group C, 19 cases in each group. In group A, the dosage of fentanyl was 1 μg/mL and the dose of propofol was 3 μg/mL; In group B, the dosage of fentanyl was 2 μg/mL and the dose of propofol was 3 μg/mL; In group C, the dosage of fentanyl was 4 μg/mL and the dose of propofol was 3 μg/mL. 10 min before anesthesia, 1 min after intubation, 20 min after pneumoperitoneum, pneumoperitoneum after postoperative 20 min，systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) were recorded in three groups； awake time postoperative after discontinuation，extubation time, duration of pneumoperitoneum, analgesia and adverse reactions were observed in three groups. ResultsCompared with 10 min before anesthesia, SBP, DBP, HR decreased 1min after intubation in both groups (P＜0.05), SBP, DBP, HR of group B and group C 20min after pneumoperitoneum were higher than those of group A(P＜0.05), SBP, DBP HR of group A and group B pneumoperitoneum after operation in 20min were higher than those of group C (P＜0.05). Pain scores, awake time and extubation time of group B were better than those of group A and group C, the difference was statistically significant (P＜0.05). The nausea, vomiting, headache and other adverse reaction in the three groups were no statistical difference (P＞0.05). ConclusionIn the surgery of gynecological laparoscopic, using the dose of 6-8 μg/mL fentanyl and 3 μg/mL of propofol intravenous anesthesia can effectively control the confining stress generated in the operation period, to ensure a good prognosis and restore hemodynamic stability.

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