ObjectiveTo investigate the clinical effects of interventional therapy in the treatment of lacunar cerebral infarction and its effect on patients′ cognitive changes. MethodsA total of 112 patients with lacunar cerebral infarction were divided into observation group and control group, 56 cases in each group. Patients in control group were treated with routine treatment; patients in observation group were treated with interventional therapy，When the catheter was involved in the stenosis or occlusion of the vessel, 500 thousand units of urokinase were injected slowly, then the thrombus were carried out guided by a micro-guidewire. The therapeutic effects and the changes of cognitive function in the two groups were compared after treatment. ResultsAfter treatment, the total effective rate of observation group was 96.43% (54/56), significantly higher than 85.71%(48/56) of control group , the difference was statistically significant (P＜0.05). Before treatment, the MMSE, MoCA scores of two groups was not statistically significant (P＞0.05); after 1 month, 6 months of treatment, the MMSE and MOCA scores of observation group were higher than those of the control group, the difference was statistically significant(P＜0.05). Before treatment, the SAS, SDS scores of two groups was not statistically significant (P＞0.05); after 1 month, 6 months of treatment, the SAS, SDS scores of observation group were lower than those of the control group, the difference was statistically significant(P＜0.05). During the treatment, the incidence of complications in observation group was 5.36% (3/56), significantly lower than 14.29% (8/56) of the control group, the difference was statistically significant(P＜0.05). ConclusionInterventional therapy in the treatment of lacunar infarction has significant effect, less postoperative complications, good psychological state of patients, and with cognitive function improved significantly; it is worthy of clinical application.

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