ObjectiveTo evaluate the clinical efficacy of endoscopic argon plasma coagulation (APC) combined with acid suppression therapy in the treatment of verrucous gastritis. MethodsA total of 264 cases with mature type verrucous gastritis were divided into treatment group and control group.Patients in treatment group were treated with APC combined with anti-acid and anti-HP treatment, then patients in control group were treated with anti-acid and anti-HP therapy. Both the two groups were treated for 6 weeks as the end point, and the gastroscopy and HP were reviewed,the clinical symptoms of two groups were relieved by the integral and the changes of the stomach and the rate of HP clearance were compared and analyzed. ResultThe clearance rate of excipuliform apophysis in the treatment group was higher than that in the control group,the difference was statistically significant(P＜0.05). Before treatment, the symptom scores of abdominal pain, heartburn, acid reflux of two groups were not statistically significant (P＞0.05); After treatment, the above symptom scores of the two groups were significantly decreased, compared with before treatment, the difference was statistically significant (P＜0.05);The symptom scores of the treatment group were significantly lower than those of the control group, the difference was statistically significant(P＜0.05). ConclusionEndoscopic argon plasma coagulation (APC) was safe and effective in treatment of verrucous gastritis, But argon plasma coagulation can not increase the clearance rate of Helicobacter pylori.

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