ObjectiveTo evaluate the efficacy of mild hypothermia treatment on patients with severe brain injury, and the impacton plasma endothelin(ET) level. MethodsA total of 50 patients with severe brain injury were divided into observation group(n=25)and control group(n=25). Patients in control group were treated with conventional therapy, and patients in observation group were treated with conventional therapy combined with mild hypothermia. The plasma ET level, intracranial pressure(ICP)and clinical prognosis were compared between the two groups. ResultsAfter treatment for 1-5 d, the plasma ET level of observation group was significantly lower than that of control group, the difference was statistically significant(P＜0.05). After treatment for 1-5 d, the ICP of observation group was significantly lower than that of control group, the difference was statistically significant(P＜0.05). In observation group, favourable prognosis in 7 cases, mild disability in 8 cases, severe disability in 6 cases, vegetable survival in 2 cases and death 2 cases. In control group, favourable prognosis in 3 cases, mild disability in 4 cases, severe disability in 10 cases, vegetable survival in 3 cases and death 5 cases. The clinical prognosis of observation group was significantly better than control group, the difference was statistically significant(P＜0.05). ConclusionThe brain protective effects of mild hypothermia may be related to the inhibition of ET secretion and reduce ICP.

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