ObjectiveTo explore the safety and efficacy of ultrasound guided percutaneous radiofrequency ablation combined with percutaneous alcohol sclerotherapy and portal vein perfusion of PVTT treatment. MethodsA total of 41 cases with primary HCC and PVTT were divided into two groups, observation group( 21 cases) were treated by percutaneous radiofrequency ablation combined with percutaneous alcohol sclerotherapy and portal vein perfusion treatment; control group(20 cases)were treated with simple percutaneous radiofrequency ablation. The survival rate and recurrence rate were compared between the two groups, and the related factors affecting the survival rate were analyzed. ResultPVTT treatment was successfully completed in 41 cases, 1 cases with liver abscess.The 6, 12, 24, 36 months survival rate of the observation group was significantly higher than that of the control group, the recurrence rate was significantly lower than that of the control group, the difference was statistically significant (P＜0.05). ConclusionUltrasound guided percutaneous radiofrequency ablation combined with percutaneous alcohol sclerotherapy and portal venous infusion chemotherapy for the treatment of PVTT obvious curative effect, can prolong the survival time of the patients and of PVTT formation has obvious treatment and prevention.

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