ObjectiveTo observe the analgesic efficacy of continuous epidural infusion of 0.2% ropivacaine in patients with liver neoplasmsundergoing percutaneous radiofrequency ablation. MethodsAfter 10 mL of epidural bolus 0.2% ropivacaine, 90 patients with liver neoplasms undergoing percutaneous radiofrequency ablation performed under epidural anesthesia by continuous infusion with three different doses of 0.2% ropivacaine were randomly divided into 3 groups，30 cases in each group: Group A were given 4 mL·h-1 ropivacaine; Group B were given 6 mL·h-1 ropivacaine; Group C were given 8 mL·h-1 ropivacaine. MAP, HR, SpO2, ADR and visual analogue scale (VAS) of all patients at time of T0 (before operation), T1 (incision), T2 (ablation), T3 (after operation) were recorded. ResultsCompared with Group A, MAP, HR, VAS of patients in Group B, Group C at time of T2 and T3 were decreased significantly (P＜0.05), and the incidence of bradycardia of patients in group C were significantly increased (P＜0.05); compared with Group B, MAP, HR, ADR of patients in Group C at time of T1, T2, T3 were decreased significantly (P＜0.05), the difference was statistically significant. ConclusionThe use of continuous epidural infusions of 0.2% ropivacaine at 4 mL·h-1, 6 mL·h-1, 8 mL·h-1 improved analgesic efficacy in patients undergoing percutaneous radiofrequency ablation. The dose of 6 mL·h-1 has more effective and safe analgesic effects than either of the other drugs alone for patients of liver neoplasms undergoing percutaneous radiofrequency ablation.

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