ObjectiveTo evaluate the prevention effect of intraperitoneal hyperthermic chemotherapy for peritoneal recurrence after colorectal cancer surgery. MethodsA total of 50 cases with colorectal cancer after surgical resection were randomly divided into normal temperature group and hyperthermia group. Patients in hyperthermia group were given hyperthermic perfusion chemotherapy after surgery,warm(43-45℃) distilled water 4 000 mL containing fluorouracil (5-FU)0.5 g/L, mitomycinC (MMC) 8 mg/L, oxaliplatin 25 mg/L, peritoneal lavage for 1h. Patients in normal temperature group were given with the same chemotherapy drugs, temperature controlled at 25-30℃, peritoneal lavage for 1h. Then Two groups were given peritoneal lavageonce again in 1 months and 2 months after surgery; before treatment, 1 month and 2 months after operation, the level of IL-2 and TNF-α were measured by ELISA method. Survival rates, intraperitoneal recurrence rate and the incidence of liver metastasis were compared. ResultsCompared with the normal temperature group, the levels of IL-2, TNF-α were significantly increased, the difference was statistically significant (P＜0.01); 3-year survival rate increased by l2.0%, while intra-abdominal metastasis rate and liver metastasis rate decreased by l2.0% and 8.0%, respectively, the differences were statistically significant (P＜0.05). ConclusionIntraperitoneal hyperthermic perfusion therapy could increases immune parameters (IL-2, TNF-α) levels, improve the anti-tumor immunity of patients, within the abdominal cavity of colorectal cancer recurrence after treatment or prevention of a certain role.

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