ObjectiveTo investigate the effect of transcatheter arterial chemoembolization (TACE) combined with CIK cell immunotherapy in the prevention of recurrence after hepatocellular carcinoma resection. MethodsA total of 140 patients with HCC treated with radical hepatectomy were analysed retrospectively.According to whether or not accepted prophylactic TACE and CIK within 2 months after hepatectomy,the patients were divided into conmined therapy group(57 cases),TACE group (41 cases) and control group(42 cases).Patients in combined therapy group were given prophylactic TACE combined with CIK immunotherapy following hepatectomy.Patients in TACE group were given prophylactic TACE following hepatectomy.Patients in control group only received supportive therapy.1-,2-,3-year cumulative recurrence rate and the independent risk factors for tumor recurrence were analyzed comparatively. Results1-,2-,3-year cumulative recurrence rate in combined therapy group were 39.9%,49.2% and 57.3%,those in TACE group were 43.5%,68.5% and 81.5%,and those in control group were 51.2%,61.3% and 68.3%,respectively.There was significant difference between combined therapy group and TACE group(P=0.040),and between combined therapy group and control group(P=0.046).There was not significant difference between TACE group and control group (P=0.800).The number of tumors was the independent risk factor for HCC recurrence. ConclusionAdjuvant TACE combined with CIK immunotherapy after HCC hepatectomy can be an effective method for reducing recurrence rate,especially in multiple liver cancer.

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