ObjectiveTo observe the effect of laparoscopic radical operation on stress response in patients with rectal cancer. MethodsA total of 76 patients with rectal cancer were selected and randomly divided into observation group and control group, 38 in each group. Patients in the observation group were performed laparoscopic radical operation, and the control group were performed traditional open surgery. The operation time, blood loss, postoperative hospital stay, postoperative fever time, intestinal function recovery time and variation of axillary temperature were compared. In addition, interleukin-6 (IL-6), tumor necrosis factor(TNF-α), C-reactive protein(CRP) and Ghrelin before and one day after surgery were compared. ResultsCompared with the control group, the operation time were significantly longer in the observation group(P＜0.05). The blood loss, postoperative hospital stay, postoperative fever time, intestinal function recovery time, postoperative axillary temperature in the observation group were significantly lower than those in the control group (P＜0.05). Both groups had significantly higher levels of IL-6、TNF-α、CRP and Ghrelin after surgery, there were significant differences between the two groups(P＜0.05). The first day after surgery, IL-6, TNF-α, CRP, Ghrelin in the observation group were lower than those in the control group,there were significant differences between the two groups(P＜0.05). The incidence of complications were not statistically different between the two groups(P＞0.05). ConclusionLaparoscopic radical operation is better than traditional open surgery in patients with rectal cancer, it relieves the stress response and had low rate of complications. It may be the proper choice in the elderly patients with rectal cancer.

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