ObjectiveTo investigate the application value of Mucosolvan during perioperative period of laparoscopic rectal cancer. MethodsEighty patients with rectal cancer were randomly divided into group A and group B,40 cases in each group. Patients in Group A were treated with Mucosolvan via intravenous administration (90mg for each dose, q.d) combined with atomization (30mg for each dose, t.i.d) for consecutive 5 days before operations, the treaments were performed the same as those of pre-operation ,while patients in Group B were administrated with same protocol only omitting the treatment of pre-operation. The conditions of postoperative expectoration, pulmonary complications,the levels of PaCO2 and PaO2 and pulmonary function of two groups were compared. ResultsPatients in Group A showed better conditions of postoperative expectoration (95% versus77.5% of Group B). After operation, A group, PaO2 was significantly higher than that of group B (P＜0.05), PaCO2 than that in group B decreased significantly (P＜0.05), preoperative ambroxol in improving expectoration and pulmonary function better than only the postoperative patients (P＜0.05). While there were no significant difference between two groups with respect to the morbidity of pulmonary complications(P＞0.05). ConclusionsPreoperative application of Mucosolvan merits good clinical potential due to the improvement of pulmonary ventilation and pulmonary function.

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