ObjectiveTo explore the clinical effect of small incision minimally invasive surgery in treatment of thyroid adenoma，and changes of prealbumin(PA), retinol-binding protein(RBP) and C-reactive protein(CRP) in patients. MethodsA total of 96 cases with thyroid adenoma were divided into experimental group and control group. The experimental group was given minimally invasive surgery(46 cases),and the control group was given traditional thyroid adenoma surgery(50 cases). The operation time, blood loss, length of incision, drainage, hospital stay,adverse events and the levels of serum PA, RBP and CRP before and after treatment were compared. ResultsThe operation time, blood loss, length of incision, drainage, hospital stay of experimental group were better than that of control group,the differences were statistically significant (P＜0.05); The incidence of postoperative complications of experimental group was 4.35%（2/46）,and the control group was 18.00%(9/50), the difference was statistically significant (P＜0.05). Before treatment, there was no significant difference in the level of PA, RBP and CRP between the two groups (P＞0.05) . After treatment,the level of serum PA, RBP and CRP of the experimental group were (0.27±0.05) g/L, (27.42±3.72) mg/L and (7.73±1.23) mg/L;the control group were (0.23±0.03) g/L, (23.68±4.03) mg/L and (9.05±1.36) mg/L,The levels of PA and RBP of the control group were significantly lower than the experimental group(P＜0.05);while the levels of CRP in the control group was significantly higher than that in the experimental group (P＜0.05). ConclusionMinimally invasive surgery treatment on thyroid adenoma has the advantage of safe ,effective and beauty,as is effective and worthy of popularization.

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