ObjectiveTo explore the clinical feasibility and application value of sentinel lymph node biopsy instead of axillary lymph node dissection for early breast cancer in primary hospital. Methods84 cases of T1-2N0M0 breast cancer patients were divided into substitution group and the cleaning group. If sentinel lymph node biopsy was negative, no axillary lymph node dissection was performed in the substitution group; cleaning group patients axillary lymph node were dissected after sentinel lymph node biopsy. Sentinel lymph node detection rate, accuracy, false negative rate and other related indicators were analyzed, and postoperative complications and the incidence of axillary recurrence were compared between the two groups. Results①The detection rate of sentinel lymph node (SLN) was 90.4% in all breast cancer patients; In cleaning group, the accuracy rate was 96.7%, the sensitivity was 92.8%, the specificity was 100%, the false negative rate was 7.1%, the false positive rate was 0. ②Complications: upper limb numbness, swelling, stiffness, muscle strength decline, changes in the shape of the armpit of substitution group were significantly lower than that of cleaning group, the difference was statistically significant (P＜0.05). ③Recurrence: among 21.5 months of follow-up, there was 1 case of axillary recurrence in the substitution group, 2 cases in the cleaning group, and no significant difference between the two groups (P＞0.05). ConclusionsApplication of methylene blue for sentinel lymph node biopsy can accurately predict early breast cancer patients with axillary lymph node metastasis, sentinel lymph node biopsy instead of axillary lymph node dissection and less postoperative complications, low recurrence rate.It can still be used in primary hospitals for surgical staging in patients with early breast cancer.

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