ObjectiveTo compare the clinical effect and safety of endovascular intervention and simple medicine therapy in treatment of ischemic cerebrovascular disease. MethodsA total of 89 patients with ischemic cerebrovascular disease were divided into intervention group(n=42) and medicine group(n=47). Patients in intervention group were treated with endovascular intervention; Patients in medicine group were treated with drugs such as aspirin, clopidogrel and atorvastatin. The improvement of blood flow of primary responsible vascular and the incidence rate,mortality rate of cerebrovascular events in follow-up period were compared between two groups. ResultsCompared with before treatment, the systolic peak flow velocity of common carotid artery, internal carotid artery, vertebral artery and basilar artery were significantly improved at 3 months and 12 months after treatment in the intervention group (P＜0.05), but there was not obviously improved in the medicine group(P＜0.05) .The systolic peak flow velocity of common carotid artery,internal caritid artery,vertebral artery and basilar artery at 3 months and 12 months after treatment in the intervention group were significantly lower than the same time point of the medicine group (P＜0.05); the incidence rate of cerebrovascular events at 3 months and 12 months after treatment in the intervention group were lower than that of the medicine group, but the difference had no statistical significance(P＞0.05).There was no significant difference of the mortality rate between the two groups(P＞0.05). ConclusionCompared with simple medicine treatment, endovascular intervention can achieve better clinical effect and safety in treatment of ischemic cerebrovascular disease.

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