目的探讨经皮冠状动脉介入(PCI)对老年缺血性心肌病患者心功能的影响。方法采用随机数字表法将88例老年缺血性心肌病患者分为观察组和对照组各44例。对照组给予基础药物治疗,观察组在对照组基础上实施PCI干预。治疗前与治疗后1个月检测血清肌酸激酶同工酶(CK-MB)、肌钙蛋白I(TnI)及脑钠肽(BNP)水平,并应用超声心动图测定左心室舒张末期内径(LVEDD)与左心室射血分数(LVEF),比较两组患者上述指标差异。结果治疗后观察组CK-MB、TnI、BNP均显著低于对照组,两组比较,差异有统计学意义(P<0.05);治疗后观察组LVEDD小于对照组,LVEF显著高于对照组,两组比较,差异均有统计学意义(P<0.05)。结论PCI可以有效改善心肌血流灌注,促进心功能的恢复,在治疗老年缺血性心肌病所致心功能不全方面具有重要意义。
ObjectiveTo investigate the influence of percutaneous coronary intervention(PCI) on cardiac function of elderly patients with ischemic cardiomyopathy. MethodsEighty-eight elderly patients with ischemic cardiomyopathy were randomly divided into observation group and control group, 44 cases in each group. The control group were given basic drug treatment according to the pathogenetic condition. The observation group, based on the control group, were given PCI treatment. Before treatment and 1 month after treatment, the levels of serum creatine kinase isoenzyme (CK-MB), troponin I (TnI) and brain natriuretic peptide (BNP) were detected. Echocardiography was used to detect left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF). The above indexes were compared between the two groups. ResultsAfter treatment, CK-MB (0.12±0.06) μg/L, TnI (0.29±0.04) ng/mL and BNP (62.21±3.12) ng/mL in the observation group were significantly lower than those in the control group [(0.23±0.15) μg/L, (0.34±0.02) ng/mL, (69.81±5.27) ng/mL] (P<0.05); LVEDD (45.43±4.35) mm of the observation group was significantly shorter than (52.11±6.12) mm of the control group , while LVEF of the observation group (52.87±6.2)% was significantly higher than (41.56±5.2)% of the control group (P<0.05). ConclusionPCI can effectively improve myocardial perfusion and promote the recovery of cardiac function. It plays an important role in the treatment of elderly patients with cardiac insufficiency induced by ischemic cardiomyopathy.