Pseudomonas aeruginosa(PA) is a common opportunistic pathogen as well as one of the main pathogens causing nosocomial infections. The clinical treatment of PA infection is becoming difficult gradually for its congenital and acquired drug resistance and its increasingly high resistance rate of many antibiotics including carbapenem. Mechanisms of drug resistance of PA are complex, which include production of βlactamases, expression of active efflux systems, lack of outer membrane proteins, production of aminoglycoside modifying enzymes, changes of antimicrobial targets, existence of integrons, and biofilms forming,etc

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