ObjectiveTo investigate the clinical effect of anterior chamber injection of cefuroxime in prevention of endophthalmitis after cataract surgery. MethodsA total of 11105 patients with senile cataract were recruited in our study, among which 4381 cases (5257 eyes) treated from September 2008 to January 2005 acted as control group, 6724 cases (8069 eyes) from October 2008 to December 2013 were treated as experimental group. The two groups were performed phacoemulsification or small incision nonphacoemulsification surgery, and artificial lens implantation. ResultsThe incidence rate of endophthalmitis in the experimental group was 0.045% (3 /6 724 cases), obviously lower than 0.297%(13/4 381 cases) in the control group, the difference was statistically significant(P＜0.01). Both of the cases with ophthalmia were cured by intravitreal and anterior chamber injection of vancomycin, ceftazidime, dexamethasone. ConclusionsIntracameral injection of cefuroxime is safe and effective in preventing postcataract endophthalmitis.

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