ObjectiveTo study the influence of acupuncture treatment on Lee’s index and concentration of insulin,serum leptin,SOCS3 of obesity rats,aimed to explore the mechanism of acupuncture on the treatment of obesity. Methodsseventy SD rats were recruited in our study. Ten rats were fed with normal diet,when sixty rats were fed with high-fat diet for 8 weeks.Thirty rats were selected randomly from 47 rats whose weight were 20% higher than that of the rats fed with normal diet,and then 30 rats were divided into model control group, nonspecific acupoint group,specific acupoint group,ten in each group. After 4 weeks of treatment, the concentration of serum leptin, insulin and SOCS3 was detected by Enzyme linked immunosorbent assay. ResultsThe body weight, Lee’s Index, concentration of serum leptin, insulin and SOCS3 of rats fed with high-fat diet increased significantly and higher than that of the control group.Compared with the control group and model group, the body weight, the Lee’s index, and concentration of serum leptin, insulin, and SOCS3 in nonspecific acupoint group and specific acupoint group both reduced significantly after acupuncture treatment. ConclusionAcupuncture can significantly improve the body weight and Lee’s index of obesity rats induced by high-fat diet, the mechanism may be related to the improvement of SOCS3, reduction the level of leptin and insulin.

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