ObjectiveTo evaluate the effect of butorphanol combined with tropisetron for preventing postoperative adverse reactions after laparoscopic gynecological surgery. Methods240 cases undergoing laparoscopic gynecological surgery were randomly divided into three groups, 80 cases in each group. After induction of general anesthesia, group 1 as control group was given 2 ml of normal saline intravenously, group II was given 5 mg of tropisetron hydrochloride intravenously, group III was given 1mg of butorphanol tartrate 1mg plus 5mg of tropisetron hydrochloride. The RSS, VAS, RS scores, the time to extubation, the time to resuscitation, as well as the adverse reactions were recorded, including extubation-induced agitation, postoperative chills, nausea, vomiting and so on. ResultsThe time to respiratory recovery, resuscitation and extubation in group III were significantly shorter than those of group Ⅱ and group Ⅰ (P＜0.05). In group Ⅲ, the RSS, VAS scores of 2h, 4h, 6h, 12h after operation were significantly better than those in group Ⅱ and group Ⅰ (P＜0.05). In group Ⅲ, the rates of postoperative nausea and vomiting (PONV), chills and extubation-induced agitation were significantly lower than those of group Ⅰ and Ⅱ (P＜0.05). ConclusionButorphanol combined with tropisetron may shorten the time to extubation and resuscitation, reduce the rates of extubation-induced agitation, PONV, and post-operative chills, worthy of clinical pomotion.

• ref