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目的探讨血管内皮细胞生长因子受体2（VEGFR2）和微血管密度（MVD）在大肠癌组织中的表达和意义。方法选择收治的大肠癌患者36例，取大肠癌组织作为观察组，相同患者癌旁正常组织作为对照组，检测VEGFR2表达和MVD计数，并分析两者与大肠癌患者病理特征的关系。结果VEGFR2在癌变组织中的阳性表达率为58.3%（21/36），显著高于正常组织22.2%（8/36），且与浸润深度增加、远处转移和淋巴转移显著相关；MVD在癌变组织中的计数为（28.6±9.4）个/HP，显著高于正常组织（10.5±3.9）个/HP，且与组织学分化程度、浸润深度、远处转移和淋巴转移显著相关，差异均具有统计学意义（P＜0.05）。结论大肠癌组织中VEGFR2表达和MVD计数高，二者皆可提示大肠癌侵袭转移。
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血管内皮细胞生长因子受体-2及微血管密度在大肠癌组织中的表达及意义
Expression and its significance of vascular endothelial growth factor receptor2 and microvessel density in colorectal cancer tissues
微创医学 201403期 页码：296-297,301
作者机构：(湖北省宜昌市第二人民医院肿瘤内科,宜昌市443000)
基金信息：（湖北省宜昌市第二人民医院肿瘤内科，宜昌市443000）作者简介：李欣（1968～），男，本科，副主任医师，
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ObjectiveTo investigate the expression of and its significance of vascular endothelial growth factor receptor 2 (VEGFR2) and microvessel density (MVD) in colorectal cancer tissues. MethodsColorectal cancer tissues of 36 patients were sampled as observation group, with their adjacent normal tissues as control group. VEGFR 2 expression and MVD count of the two groups were detected, and their relationships with the pathological features of colorectal cancer were analyzed. ResultsThe positive rate of VEGFR 2 in cancerous tissues was 58.3% (21/36), obviously higher than 22.2% (8/36)in normal tissue, and significantly correlated with depth of invasion and distant metastasis(all P＜0.05). MVD count in cancerous tissues was (28.6 ± 9.4) /HP, obvious higher than (10.5 ±3.9)/HP of normal tissues, and significantly correlated with histologic differentiation, invasion depth, distant metastasis, and lymph node metastasis (all P＜0.05). ConclusionBoth VEGFR 2 expression and MVD count in colorectal cancer tissues can indicate the metastasis of colorectal carcinoma
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