The important role of apolipoprotein in lipid metabolism becomes a current research hotspot in both preclinical and clinical medicine. The apolipoprotein affects not only the serum level of triglyceride, but also the metabolism of hyperdensity lipoprotein cholesterol in serum. The genic polymorphism of apolipoprotein A5 goes together closely with the serum level of it, cardiovascular and metabolic diseases such as coronary disease, stroke, diabetes, angiosclerosis and so on