ObjectiveTo explore the feasibility and clinical value of cervical injection of pituitrin to reduce the risk of intraoperative bleeding during c ervical loop electrosurgical excision procedure. Method90 patients with cervical intraepithelial neoplasia (CIN) undergoing LEEP surgery were divided into research group and control group, 45 cases for each. Lidocaine plus vasopressin was injected on both sides of the cervix during LEEP surgery in the research group, while lidocaine alone was used in the control group. Blood loss and operative time were compared between groups. ResultsThe blood loss of the research group was significantly less than that of the control group and the operative time of the research group was significantly shorter than that of the control group (P＜0.05). The heart rate of the research group rose up to a maximum value 35 seconds during surgery, significantly higher than that of the control group, (P＜0.05), Then the heart rate began to decline. The heart rates on the 1st minute, 5th minute and 10th minute during surgery showed no significant difference between groups(P＞0.05). The blood pressure between two groups showed no significant difference (P＞0.05). The postoperative vaginal discharge, bleeding volume and duration of hospital stay was significantly lower in the research group (P＜0.05). The rates of postoperative cervical stenosis, adhesions, cervical columnar epithelium valgus (polypoid hyperplasia) in the research group were significant lower(P ＜0.05). ConclusionCervical injection of pituitrin during cervical loop electrosurgical excision procedure can significantly reduce the risk bleeding, worthy of clinical promotion.

• ref