Objective To compare the effects of sufentanil with fentanyl combined with propofol in intravenous anesthesia. Methods 150 patients undergoing surgical operation were randomly divided into observation group and control group, 75 cases in each group. The observation group was given sufentanil and propofol intravenous anesthesia, the control group received fentanyl and propofol intravenous anesthesia. The recovery time and hemodynamics changes were compared between the two groups. Results In the observation group, anesthesia duration, called the open time, conscious verbal time were (86.35±25.63) min, (6.02±2.23) min, and (13.14±2.71) min, while in the control group they were (95.63±23.78) min, (19.11±4.92) min, and (25.65±9.02) min. The postoperative recovery time of the observation group was significantly shorter than that of the control group (P＜0.05). Compared with T0, the blood pressure, heart rate, heart rate pressure product were decreased significantly (P＜0.05), and no significant differences were observed between two groups (P＞0.05). The blood pressure, heart rate and the rate pressure product at T2 period were lower than those at T0 period in the control group (P＜0.05), while there were no differences between the T2 indexes and T0 indexes in the observation group (P＞0.05). The T2-T6 rate pressure product of observation group was significantly lower than those of the control group (P＜0.05). Conclusion Sufentanil combined with propofol in intravenous anesthesia, can greatly shorten the postoperative recovery time, significantly reduced the impacts on hemodynamics.

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