【Abstract】 Objective To explore lymphocyte subsets and NK cells activity in peripheral blood of nasopharyngeal carcinoma patients, and their relations with the IgA/VCA antibody level against EB virus before and after treatment, lymph node metastasis, and clinical stage. Method Flow cytometry (FCM) was used to detect peripheral blood lymphocyte subsets and NK cells percentage of 58 patients with nasopharyngeal carcinoma before and after treatment. Results (1)After treatment, CD8+cells were significantly increased, CD4+ and CD19+ cells and CD4+/CD8+ ratio were decreased significantly, the differences were statistically significant (P＜0.05), the change of CD3+ cell showed no statistical significance (P＞0.05); (2) Before treatment, the level of CD19+ NK cell in those with the high titer of EB virus IgA/VCA antibody was higher than that of those with the low titer (P＜0.05), the rest of the index had no significant difference (P＞0.05). After treatment, there were no significant differences in these indicators (P＞0.05); (3) Between those with lymph node metastasis and without lymph node metastasis before treatment, the CD19+ NK cell level of the former was significantly increased (P＜0.05), the rest of the index difference had no statistical significance (P＞0.05). There was no statistically significant difference after treatment (P＞0.05); (4) The CD19+ cell level of cases on the Ⅲ-Ⅳ stage was higher than that of those on the Ⅰ-Ⅱ stage before treatment (P＜0.05), the rest of the index difference has no statistical significance (P＞0.05). There were no statistically significant differences in the indicators after treatment, (P＞0.05). Conclusion There is no evidence of a correlation between the state of the organism cellular immunity in patients with nasopharyngeal carcinoma (NPC) and local lymph node or distant metastasis, and cellmediated immunity can be significantly improved after treatment.

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