Objective To explore the efficacy of microneedle combined with different drugs on superficial parts vascular lesions.Methods 30 Laiheng chickens were randomly divided into 3 groups,each group of 10 only.Cockscomb as an animal model of vascular lesions,microneedle combined with pingyangmycin(group A) and triamcinolone acetonide(group B) were adopted,normal comb as control group C.Dynamic observation of dilated organization general and pathological changes,capillary number of change were done 1,2,3,4 weeks after processing respectively.Results The comb in experimental groups showed shallow and pale,in varying degrees,microscopic observation showed that dermal capillary decreased,group A was significantly greater than group B.Conclusion Roller grinding of microneedle and drug interactions can be effective on the dilated blood capillary,and the effect of pingyangmycin is better than that of triamcinolone acetonide.

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