Objective To investigate the clinical effect of rhubarb peony decoction assisted laparoscopic choledocholithotomy in the treatment of calculus of common bile duct. Methods A total of 110 patients with calculus of common bile duct were selected as research objects. According to the random number table method, patients were divided into a control group (treated with laparoscopic choledocholithotomy) and an observation group (treated with rhubarb peony decoction enema therapy on the basis of the control group), with 55 cases in each group. The clinical efficacy, visual analogue scale (VAS) score, gastrointestinal dysfunction score, hepatobiliary function index and inflammatory factor levels before and after treatment were compared between the two groups. Results The clinical efficacy of the observation group was better than that of the control group, with statistically significant difference (P<0.05). After treatment, the VAS score and gastrointestinal dysfunction score of the two groups were significantly lower than those before treatment, and the above scores in the observation group were lower than those of the control group, with statistically significant differences (all P<0.05).After treatment, the levels of serum alanine transaminase(ALT), aspartate transaminase (AST), γ-glutamyl transpeptidase (γ-GT), total cholesterol (TC) and total bilirubin (TBiL) in the two groups were significantly decreased before treatment, among which the levels of serum ALT, AST and γ-GT were lower, and the levels of TC and TBiL were higher in the observation group than those in the control group, with statistically significanct differences (all P<0.05). Compared with before treatment, the serum TBA levels of the two groups were increased, and the serum total bile acid (TBA) level of the two groups were incresed, which was higher in the observation group than that in the control group, with statistically significant differences (all P<0.05). Compared with before treatment, the levels of serum procalcitonin (PCT) and C-reactive protein (CRP) in the two groups were significantly decreased after treatment, and the levels of serum PCT and CRP in the observation group were lower than those in the control group, with statistically significant differences (all P<0.05). Conclusion Rhubarb peony decoction assisted laparoscopic choledocholithotomy can effectively improve the postoperative gastrointestinal function and hepatobiliary function of patients with calculus of common bile duct, reduce the level of inflammatory factors, and obtain significant clinical efficacy.

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