Objective To explore the application effect of quadratus lumborum block at the lateralsupra-arcuate ligament (QLB-LSAL) in laparoscopic renal and perirenal surgery. Methods Forty-five patients who underwent laparoscopic renal or perirenal surgery were selected as study subjects and randomly divided into group Q (n=22) and group T (n=23). Under conventional general anesthesia, patients in group Q were treated with ultrasound-guided lateral QLB-LSAL, while patients in group T were treated with ultrasound-guided transversus abdo-minal plane block (TAPB) (both groups were given unilateral single injection of 0.375% ropivacaine 20 mL ). The mean arterial pressure (MAP) and heart rate were compared between the two groups at the time of entering the operating room (T0), at the beginning of surgery (T1), at the end of surgery (T2), at the time of awakening (T3), and at the time of leaving the recovery room (T4). The Numerical Rating Scale (NRS) scores of static and dynamic pain were compared at the time of postoperative awakening and at 12 hours, 24 hours and 48 hours after surgery. The dosage of analgesic medication used during surgery and within 48 hours after surgery were compared. The postoperative rapid recovery indicators (including the time of awakening, postoperative intestinal exhaust, postoperative ambulation and postoperative discharge), and the occurrence of postoperative complications (incidence of dizziness, headache, nausea and vomiting, nerve block complications) were compared. Results There was no statistically significant difference in MAP and heart rate between the two groups at each time point (all P>0.05). There was no statistically significant difference in the dynamic and static NRS scores between the two groups of patients at postoperative awakening, 12 hours, and 48 hours after surgery. Twenty-four hours after surgery, there was no statistically significant difference in the dynamic NRS scores between the two groups of patients (P>0.05), but the static NRS scores of patients in the group Q were significantly higher than that in the group T (P<0.05). There was no statistically significant difference in the total dosage of analgesic medication used during and 48 hours after surgery, as well as the postoperative rapid recovery indicators and incidence of complications between the two groups of patients (all P>0.05). Conclusion The analgesic effect of QLB-LSAL is comparable to that of TAPB, and it can also provide a safe and effective auxiliary analgesic effect for laparoscopic renal and perirenal surgery, which is worthy of further clinical application and promotion.

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