Objective To investigate the related factors intraoperative bleeding in patients with colorectal polyps undergoing endoscopic mucosal resection (EMR). Methods A total of 471 patients with colorectal polyps who received EMR were enrolled as research objects and divided into an observation group and a control group based on whether there was intraoperative bleeding. Clinical data such as basic information, pathological factors and surgical related factors of patients were collected, and the influencing factors of intraoperative bleeding were analyzed by multivariate Logistic regression model. Results A total of 38 patients had intraoperative bleeding, with an incidence of 8.07%. The results of multivariate logistic regression analysis showed that the location of polyps, number of polyps, and number of titanium clips were independent influencing factors for intraoperative bleeding in EMR (all P<0.05). Intraoperative bleeding was correlated with postoperative bleeding and postoperative fasting time (P<0.05). Conclusion The location of polyps, number of polyps, and number of titanium clips are independent influencing factors of bleeding during EMR of intestinal polyps. Clinical prevention should be carried out according to the influencing factors to reduce the incidence of postoperative related complications.