目的探讨胃肠道神经内分泌癌的诊断和微创治疗。方法对2000年到2009年在该院住院手术治疗的胃肠道神经内分泌癌36例患者的临床资料进行回顾性分析。结果胃肠道神经内分泌癌的主要临床表现为腹部疼痛、解黏液血便和腹泻,肿瘤病灶多数≤2cm,肿瘤组织中Ⅱ型生长抑素受体阳性表达率为80%,微创手术治疗疗效确切,随访时间9~86个月,无复发病例。结论超声内镜和螺旋CT可提高胃肠道神经内分泌癌的发现率和诊断率,微创手术治疗安全、有效。
Objective To investigate the diagnosis and minimally invasive treatment of gastrointestinal neuroendocrine carcinomas.Methods Clinical data of 36 patients with gastrointestinal neuroendocrine carcinomas during 2000 to 2009 at the People′s Hospital of Guangxi Zhuang Autonomous Region were analyzed retrospectively.Results The major symptoms of gastrointestinal neuroendocrine carcinomas included upper abdominal pain,gut bleeding and diarrhea.Most of the tumor’s size was ≤ 2 cm.The positive expression rates of somatostatin receptor II(SSTR-II) in the tumor was 80%.The minimally invasive treatment was effective. Patients were followed for 9 to 86 months,and there was no recurrence.Conclusions Endoscopic ultrasonography (EUS) and spiral CT could increase the rate of detection and diagnosis of gastrointestinal neuroendocrine carcinomas,and it is concluded that those minimally invasive treatments were safe and effective.