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基质金属蛋白酶-9和血管内皮生长因子在妊娠期高血压疾病中的表达及意义
Expression and significance of matrix metalloproteinase-9 and vascular endothelial growth factor in hypertensive disorders in pregnancy

微创医学 201004期 页码:338-339

作者机构: 广西东兰县人民医院妇产科; 广西医科大学第一附属医院妇产科

基金信息: 【基金】 广西壮族自治区卫生厅科研课题(Z2006041)

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目的探讨基质金属蛋白酶-9(MMP-9)及血管内皮生长因子(VEGF)在妊娠期高血压疾病发病机制中的作用。方法采用酶联免疫吸附(ELISA)法检测20例妊娠期高血压疾病患者(实验组)和20例正常妊娠孕妇(对照组)血清MMP-9及VEGF水平。结果妊娠期高血压疾病患者血清MMP-9及VEGF水平显著低于正常对照组(均P<0.05)。结论妊娠期高血压疾病患者MMP-9及VEGF表达水平下降,孕妇血清MMP-9及VEGF水平变化在妊娠期高血压疾病的发病机制中有重要作用。

 

Objective To evaluate the role of matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor(VEGF) in the pathogenesis of hypertensive disorders in pregnancy.Methods Serum MMP-9 and VEGF levels were determined in 20 patients with hypertensive disorders in pregnancy and 20 healthy pregnancy women by ELISA assay.Results Serum MMP-9 levels and VEGF were significantly lower in the patients with hypertensive disorders in pregnancy than those in healthy controls (P<0.05).Conclusion MMP-9 and VEGF levels may play a pivotal role in the pathogenesis of hypertensive disorders in pregnancy

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