Objective To investigate the clinical effect of low frequency impulse electrostimulation combined with electro-acupuncture in the treatment of urinary retention after stroke. Methods A total of 160 patients with urinary retention after stroke were selected as study objects and divided into observation group and control group with 80 cases in each group by random number table method. Patients in the control group were treated with low frequency impulse electrostimulation on the basis of symptomatic treatment, while the observation group were treated with electro-acupuncture on the basis of the control group. The treatment-related indicators (residual bladder volume, first urination time after treatment, hospital stay and catheter indwelling duration), treatment effective rate, incidence of urinary tract infection and life quality were compared between the two groups. Results After treatment, the residual bladder volume in both groups was less than that before treatment, which was less in the observation group than in the control group; and the first urination time, hospital stay and catheter indwelling duration in the observation group were obviously shorter than those in the control group. After 2 weeks of treatment, the total treatment effective rate of the observation group was higher than that of the control group (88.75% vs. 75.00%). During the treatment, the incidence of urinary tract infection in the observation group was lower than that in the control group (18.75% vs. 48.75%). After treatment, the scores of all dimensions of the 36‑item Short‑Form in the observation group were higher than those in the control group, with statistically significant differences (all P<0.05). Conclusion Low frequency impulse electrostimulation combined with electro-acupuncture in the treatment of urinary retention after stroke can effectively improve the urination function and clinical symptoms of patients, reduce the incidence of urinary tract infection during the treatment, and improve patients' life quality.