Objective To investigate the clinical effect and safety of severed finger replantation and non-severed finger replantation in the treatment of complete amputation of distal finger. Methods A total of 100 patients with complete amputation of distal finger were selected and divided into observervation group and control group according to treatment plan, with 50 cases in each group. The control group was treated with non-severed finger replantation, and the observation group was treated with severed finger replantation. The survival of severed finger, occurrence of complications, recovery of sensation and hand function were compared between the two groups. Results Compared with the control group, the observation group had higher complete survival rate of severed finger (70.00% vs. 34.00%) and lower incidence of complications (8.00% vs. 26.00%) (P<0.05). At 6 months and 12 months after operation, the monofilament tactile sensation and two-point discrimination of the observation group were better than those of the control group (P<0.05). Twelve months after operation, the presence rate of shallow pain in the observation group was higher than that in the control group (76.00% vs. 46.00%), and the positive rate of blister test in O'Rain warm water was lower than that in the control group (14.00% vs. 36.00%), the scores of motor function, daily activities, sensory recovery, blood circulation status, appearance and work recovery were higher than those in the control group (all P<0.05). Conclusion Compared with non-severed finger replantation, replantation of severed finger can further improve the survival rate of severed finger, promote sensory recovery and improve hand function, with low incidence of complications in the treatment of complete amputation of distal finger.