微创医学

目的比较来曲唑和克罗米酚两种微刺激方法的临床结局。方法用微刺激方法促排辅助生殖技术(ART)助孕的卵巢储备功能不良的患者共48例,促排卵80周期,分为来曲唑组(CC组46周期)和克罗米酚组(LE组34周期),分别比较两组患者HCG日≥14 mm卵泡数、子宫内膜厚度、形态和血清E2、LH、P水平,以及平均获取卵数、可供移植胚胎数、妊娠率、种植率、流产率。结果两组的HCG日内膜厚度和E2有显著性差异,而HCG日LH、P无显著性差异;CC组中有7周期HCG日子宫内膜厚度<7.0 mm,LE组中有1周期。>14 mm卵泡数、获卵数、可供移植胚胎数、妊娠率、种植率、流产率两组均无显著性差异。结论两种促排卵方案对于卵巢储备低下的患者均是有效的促排方案,CC组促排效果比LE组略胜一筹。

Objeetive To compare the clinical outcome of microstimulation method of letrozole and clomifene． Methods 48 cases of ovaries reserve eacergasia(80 cycles)planned to receive microstimulation of ART were divided into CC group(administrated with letrozole，46 cycles)and LE group(administrated with clomifene，34 cycles)．Follicle nun— bers(D≥14mm)，thickness and morphous of endometrium，sero—E2，sero—LH，sero—P on HCG day，average harvesting ovum numbers，ET—feasible embryo numbers，pregnancy rates，implantation rates，abortion rates of the two groups were compared． Results Thickness of endometrium and sero—E2 on HCG day had significant diference between two groups，but sero—LH and sero·P not．There were 7 cycles which thickness of endometrium on HCG day was <7．0mm in group CC，compared with 1 cycles in group LE．There was no significant diference in follicle nulnbers(d≥14mm)，harvesting ovum numbers，ET-feasi— ble embryo numbers，pregnancy rates，implantation rates，and abortion rates between two groups．Conclusions Both mi· crostimulation methods are efective to patients with ovaries reserve cacergasia，whereas letrozole shows slight superiority to domlfene．

ref