Objective To make a comparative analysis of the application effects of simple suture and purse-string suture embedding in the treatment of complex appendiceal stump in laparoscopic surgery. Methods The clinical data of 102 acute appendicitis patients with severe inflammation at the root of the appendix who received emergency laparoscopic surgery were retrospectively collected, and they were divided into purse-string suture embedding group and simple suture group according to the surgical method, and the propensity score matching analysis was performed by Logistic regression model. After propensity score matching, the operation time, intraoperative blood loss, occurrence of postoperative complications (appendiceal stump fistula, incision infection and abdominal residual infection), first anal exsufflation time after surgery, indwelling duration of abdominal drainage tube and hospital stay were compared between the two groups. Results Thirty-three pairs of patients in the two groups were successfully matched by propensity score matching. The operation time in the simple suture group was shorter than that in the purse-string suture embedding group, while the indwelling duration of abdominal drainage tube in the purse-string suture embedding group was shorter than that in the simple suture group (all P<0.05). There were no statistically significant differences in the intraoperative blood loss, incidence of postoperative complications, first anal exsufflation time after surgery and hospital stay between the two groups (all P>0.05). Conclusion For patients with acute appendicitis with severe inflammation of the appendiceal root, simple suture and purse-string suture embedding are both safe and effective in the treatment of appendiceal stump, while the operation of simple suture is more convenient and the operation time is relatively short. Nevertheless, purse-string suture embedding is more in line with the physiological repair process of the body after operation.