Objective To conduct a comparable analysis of coronary angiography (CAG) and intravascular echocardiography (IVE) assisted percutaneous coronary intervention (PCI) technique in the treatment of coronary heart disease. Methods Ninety patients with coronary heart disease who treated by PCI were selected as research objects. According to the different imaging techniques used in PCI, patients were divided into CAG group (CAG technique, 45 cases) and IVE group (IVE technique, 45 cases). The surgical conditions, clinical outcomes and complications of the two groups were compared. Results The maximum pressure of balloon dilation stent, the maximum lumen diameter and the minimum lumen diameter after PCI in the IVE group were greater than those in the CAG group, the good rate of stent implantation effect was higher than that in the CAG group (97.78% vs. 82.22%), and the incidence of complications, incidence of hospitalization for angina pectoris and myocardial infarction were lower than those in the CAG group (all P<0.05). Conclusion Compared with CAG, IVE can further improve the effect of stent implantation, reduce the incidence of complications and improve the clinical outcomes of patients in the treatment of coronary heart disease with assisted PCI technique.