Objective To explore the rehabilitation effect of resistance training combined with aerobic exercise in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods A total of 106 AMI patients were selected as the research objects. Among them, 51 patients who underwent routine rehabilitation exercise after PCI were set as the control group. At the same time, 55 patients who received routine rehabilitation exercise combined with resistance training and aerobic exercise, and whose general data were comparable to those of the control group were set as the observation group. The left ventricular ejection fraction (LVEF), left ventricular end-systolic dimension (LVESD), left ventricular end-diastolic dimension (LVEDD), 6-minute walk distance (6MWD), postoperative self-care ability (Barthel index scale) score and quality of life (SF-36) score were compared between the two groups. Results There were no statistically significant differences in LVEF, LVESD, LVEDD, and 6MWD between the two groups 3 days after PCI (all P>0.05). Six months after PCI, LVEF and 6MWD increased significantly, LVESD and LVEDD decreased significantly in both groups, and LVEF and 6 MWD of the observation group were significantly higher than those of the control group, LVESD and LVEDD were significantly smaller than those of the control group, with statistically significant differences (all P<0.05). There was no statistically significant difference in Barthel index scale score between the two groups 3 days after operation (P>0.05). Before discharge and 6 months after operation, the scores of Barthel index scale in the two groups were significantly increased, and the observation group was higher than the control group, with statistically significant differences (all P<0.05). Six months after operation, the scores of SF-36 in the observation group were significantly higher than those in the control group in terms of physiological function, physical pain, role-physical, vitality, mental health, social function, general health status and expressive role, with statistically significant differences (all P<0.05). Conclusion The combination of resistance training and aerobic exercise in AMI patients after PCI can effectively improve their cardiac function, motor function and self-care ability, and improve their postoperative quality of life.