Objective To compare the clinical value of misoprostol with intubation for cervical priming prior to operative hysteroscopy.Methods 120 women undergoing hysteroscopy were randomly allocated into two groups.The group A received 400 mg of misoprostol rectally while the group B received cervical intubation for cervical priming.The subjective pain scores,intraoperative cervical dilatation and leakage,clarity of the hysteroscopic field,operation duration,bleeding volume and postoperative body temperature were assessed and compared between the two groups.Results The subjective pain scores were significantly lesser in group A than in group B(2.65±1.14 vs 3.31±1.56,P=0.009).The success rate of cervical dilatation in group A and B were 86.67% and 70%,respectively,the difference was significant (P=0.027).7 women in the group A and 11 in the group B had cervical leakage,however,the difference was not significant (P=0.31).Group A showed higher rate of clarity in the hysteroscopic field (90% vs 63.33%,P=0.001).No significant difference existed between group A and group B in the operation duration (31.5±8.93 min vs 28.3±9.73 min,P=0.059) and operative bleeding volume (15.33±6.16ml vs 16.66±7.35ml,P=0.284).There was 6 women in group A and 14 women in group B had a slight fever during 2 days after the operation,the difference was significant(P=0.015).Conclusion Administration of rectal misoprostol could facilitate cervical priming satisfactorily,proved to be an effective and safe methods of cervical dilatation prior to operative hysteroscopy.

无