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目的探讨Ⅲ型前列腺炎(CCPS)治疗前后血清前列腺特异性抗原(PSA)变化的临床意义。方法对经过筛查出的260例PSA≥4 ng/mL的Ⅲ型前列腺炎患者,在治疗前后行PSA检测并根据治疗前、后PSA水平及前列腺穿刺活检的结果分A、B、C三组进行对比分析,了解各组治疗前后PSA水平及前列腺癌诊断阳性率。结果 A组PSA平均值由治疗前的(6.54±1.86)ng/mL降至治疗后的(3.28±1.86)ng/mL,差异均有显著性统计学意义(P<0.01);B、C组治疗前后PSA值比较差异均无统计学意义;治疗后前列腺癌诊断阳性率明显高于治疗前,差异均有显著性统计学意义(P<0.01)。结论 PSA可用于监测前列腺炎预后情况,对于治疗后其PSA≥4 ng/mL的患者,活检可提高诊断阳性率,对早期筛查前列腺癌有重要的临床意义。
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Ⅲ型前列腺炎治疗前后血清PSA变化的临床意义
The clinical significance of the changes in serum PSA before and after the treatment of type Ⅲ prostatitis
微创医学 201106期 页码：509-512
作者机构： 广西中医学院第一附属医院泌尿外科； 广西壮族自治区民族医院泌尿外科； 广西崇左市宁明县人民医院外科； 广西南宁市横县第二人民医院外科
基金信息： 收稿日期: 2011-08-27
【基金】 广西科学研究与技术开发计划项目(任务书编号:桂科攻0816004-28);广西医疗卫生重点科研课题(合同编号:重200822)
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- 英文简介
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Objective To study the clinical significance of the changes in serum PSA before and after the treatment of Type Ⅲ prostatitis． Methods 260 patients with Type Ⅲ prostatitis with PSA≥4 ng /ml were screened out and divided into three groups of A，B and C according to PSA levels and prostate biopsy before and after treatment． PSA levels and positive rate of diagnosis of prostate cancer PSA were studied． Results Average value of PSA was reduced from ( 6． 54 ± 1． 86 ) ng /ml of pre-treatment to ( 3． 28 ± 1． 86) ng /ml of post-treatment in group A，and with statistical significance ( P ＜ 0． 05) ，but there was no statistical difference in PSA levels in group B or group C． Positive diagnosis rate of prostate cancer after treatment was significantly higher than before treatment( P ＜ 0． 05) ． Conclusion PSA can be used to monitor the prognosis of prostatitis． For patients with PSA≥4 ng /ml after the treatment，biopsy can increase positive diagnostic rate，indicating its clinical significance in screening for prostate cancer．
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