Objective To investigate the clinical effect of laparoscopic repair of gastroduodenal ulcer perforation，so as to improve the level of clinical treatment． Methods The clinical data of 126 cases gastroduodenal ulcer perforation were retrospectively reviewed． 63 cases were performed laparoscopically，and 63 cases underwent open procedure． The clinical effect were compared respectively． Results The operative time，intraoperative blood loss，postopertive recovery time of bowel movement，hospitalization，wound infection and lung infection in the laparoscope group were superior than in the open group，all with statistical significance( P ＜ 0． 01) ． Conclusion The laparoscopic operation for gastroduodenal ulcer perforation can be considered as safe as the open operation and has advantages such as minimal incion，fewer postoperative complications and rapid recovery．

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