Objective To investigate the clinical effect of single incision minimally invasive rotary resection of inframammary crease in the treatment of multiple breast masses. Methods A total of 225 patients with multiple breast masses were selected as the research object, among which 105 patients who treated with traditional minimally invasive rotary resection of breast masses were selected as the control group, and 120 patients who received single incision minimally invasive rotary resection of inframammary crease at the same time, and the general data was comparable with those of the control group were selected as the observation group. The operation related indexes, postoperative efficacy, postoperative complications and incision aesthetic satisfaction were compared between the two groups. Results The operation time and incision healing time of the observation group were shorter than those of the control group, and the visual analogue scale (VAS) score was lower than that of the control group, with statistically significant differences (all P＜0.05). There was no significant difference in intraoperative blood loss and clinical efficacy between the two groups (all P＞0.05). The incidence of postoperative complications in the observation group was lower than that in the control group (5.83% vs. 18.09%), with statistically significant difference (P＜0.05). The incision aesthetic satisfaction of the observation group was better than that of the control group, and the difference was statistically significant (P＜0.05). Conclusion Single incision minimally invasive rotary resection of inframammary crease in the treatment of multiple breast masses can not only achieve the effect of traditional minimally invasive rotary resection of breast masses, but also shorten the operation time, reduce the incidence of postoperative complications, and improve the incision aesthetic satisfaction, which has clinical popularization value.

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